Help for cytotoxic-T-cell responses is mediated by CD40 signalling
Article Abstract:
Cytotoxic T Lymphocytes (CTLs) kill target cells bearing antigens, such as cells infected with viruses. They can act alone, but often need help from CD4-positive helpers, and the help must be supplied in such a way that both helper and killer cells recognize antigen on the same target cell bearing antigens. Signalling through CD40 on cels bearing antigens is a way of replacing the requirement for helper cells, and help is mediated by this signalling.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Autoimmune diabetes as a consequence of locally produced interleukin-2
Article Abstract:
Autoimmune diabetes may result from the combination of autoreactive T cells and the lymphokine interleukin-2. Cell differentiation in the thymus produces these auto- or self-reactive T cells whose immunological effect was tested using transgenic mice carrying the gene for the class I molecule H-2Kb in the insulin-generating pancreatic beta-cells. Crossing these mice with transgenic mice expressing interleukin-2 in the beta-cells produced diabetes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells
Article Abstract:
A new mechanism protects against autoimmunity and involves CD30. CD30-deficient islet-specific CD8-positive T cells are about 6,000 times more autoaggresive than wild-type cells. In the absence of CD30 signalling, cells activated by the CD95 dependent cross-tolerance mechanism, are able to proliferate on secondary encounter with antigen on pancreatic islets. CD30 signalling thus restricts the proliferative potential of CD8 effector T cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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