Highly efficient endogenous human gene corrections using designed zinc-finger nucleases
Article Abstract:
A general solution is reported using two fundamental biological processes of DNA recognition by C2H2 zinc-finger proteins and homology-directed repair of DNA double-strand breaks. The zinc finger nucleases designed against an X-linked severe combined immune deficiency mutation in the IL2R gamma gene yielded more than 18% gene-modified human cells without selection.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Balancing regeneration and cancer
Article Abstract:
Stem/progenitor-cell proliferation, despite ensuring the benefits of tissue repair and regeneration, also adversely affect tissues by often putting them at risk of hyperproliferative diseases, the most deadly of which is cancer. Scientists have found out that the tumor-suppression protein [p16.sup.INK4a] can mitigate such risk.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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The DNA sequence and biological annotation of human chromosome 1
Article Abstract:
The finished sequence and biological annotation of human chromosome is reported. Patterns of sequence variation reveal signals of recent selection in specific genes that may contribute to human fitness and also in regions where no function is evident.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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