IKAP is a scaffold protein of the IvarKappaBeta kinase complex
Article Abstract:
The transcription factor NF-varKappaBeta is involved in coordinating the activation of many genes in response to pathogens and pro-inflammatory cytokines. IKK-alpha has been independently discovered as a NF-varKappaBeta-inducing kinase (NIK)-associated protein in a yeast, but it is not known if NIK is part of the IKK complex. Interleukin-1-inducible IKK complexes containing NIK, IKK-alpha, IKK-beta, IvarKappaB-alpha, NF-varKappaB/RelA and a protein of Mr 150K, was isolated. It is shown that IKAP is a scaffold protein and a regulator for kinases involved in pro-inflammatory cytokine signalling.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Some like it hot: spicing up ion channels
Article Abstract:
Researchers have identified the protein comprising the receptor for capsaicin, the molecule that makes chilli peppers seem hot, using an innovative expression-cloning strategy. The receptor was found to be activated by raised temperature, indicating its transduction of painful thermal stimuli in vivo. This could have indications for the clinical management of chronic pain.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Enter a polypeptide messenger
Article Abstract:
A study of the binding of the cationic secretory protein lactoferrin to DNA shows that lactoferrin binds to DNA under tough conditions with distinct sequence specificity. This intracellular interaction also results in transcriptional activation. Lactoferrin, is thus, a secretory, membrane-permeable transcription factor and DNA-binding protein.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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