Identification of the breast cancer susceptibility gene BRCA2
Article Abstract:
The breast cancer susceptibility gene BRCA2 is present on the 13q12-q13 chromosome. Six different mutations detected in the breast-cancer families are due to the BRCA2 gene. Northern analysis indicates that BRCA2 is encoded by a transcript of 10-12 kb, present in the normal breast epithelial cells, breast cancer cell line MCF7, and the placenta. The sequence of 2329 amino acid encoded by the BRCA2 gene is different from the normal DNA sequences. The mapping of BRCA2 is described.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Understanding the target
Article Abstract:
Mutations in the epidermal growth factor receptor gene (EGFR) in a subset of lung cancers make the disease more responsive to treatment. New studies provide evidence that most lung cancers that respond to gefitinib, have an activating EGFR mutation and the responses to gefitinib in clinical trials were not flukes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Chromosomally unstable mouse tumors have genomic alterations similar to diverse cancers
Article Abstract:
The article explains how mouse models and human cancers were compared to study the alterations connected to cancer by using multiple genome analysis technologies.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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