Identification of a tumour suppressor network opposing nuclear Akt function
Article Abstract:
A demonstration that the (PML) tumour suppressor prevents cancer by inactivating phosphorylated AKT inside the nucleus and that Pml deficiency on its own leads to tumorigenesis in the prostate is presented. Results reveal that Pml orchestrates a nuclear tumour suppressor network for inactivation of nuclear pAkt, and thus highlight the importance of AKT compartmentalization in human cancer pathogenesis and treatment.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Identification of a tumour suppressor network opposing nuclear Akt function
Article Abstract:
A demonstration that the (PML) tumour suppressor prevents cancer by inactivating phosphorylated AKT inside the nucleus and that Pml deficiency on its own leads to tumorigenesis in the prostate is presented. Results reveal that Pml orchestrates a nuclear tumour suppressor network for inactivation of nuclear pAkt, and thus highlight the importance of AKT compartmentalization in human cancer pathogenesis and treatment.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Taking apart a cancer protein
Article Abstract:
Evidences are provided to reveal the necessity of fusion protein for acute promyelocytes leukemia (APL). In APL cancerous cells harbour a chromosome translocation that fuses the promyelocytic leukemia (PML) gene to the gene for retinoic acid receptor-alpha (RAR alpha), giving rise to fusion proteins, PML-RARalpha and RARalpha-PML.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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