Increased cell-to-cell variation in gene expression in ageing mouse heart
Article Abstract:
Increased transcriptional noise in aged tissue is tested by dissociating single cardiomyocytes from fresh heart samples of both young and old mice, followed by global mRNA amplification and quantification of mRNA levels in a panel of housekeeping and heart-specific genes. Results reveal that the heterogeneity of gene expression levels already prevalent among cardiomyocites from young heart was elevated at old age.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
Article Abstract:
A study reveals a highly significant correlation between the liver transcriptome of old mice and a mouse model of progeroid syndrome. It is concluded that a known regulator of lifespan and it is concluded that unrepaired cytotoxic DNA damage induces a highly conserved metabolic response mediated by the IGF1/insulin pathway.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Chromatin unbound
Article Abstract:
Sir2 proteins slow ageing in yeast by locking chromatin, the DNA and proteins in chromosomes into a stable, silent state. Inactivating a Sir2 family protein in mice causes premature ageing and genome instability.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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