Mitochondrial endonuclease G is important for apoptosis in C. elegans
Article Abstract:
Research describing the DNA degradation process during apoptosis is presented. In particular the characterization of the cps-6 gene and its relation to the cell death protease CED-3 of Caenorhabditis elegans is investigated.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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Endonuclease G is an apoptotic DNase when released from mitochondria
Article Abstract:
Research describing endonuclease G is presented. In particular the caspase independent apoptopic pathway initiated from the mitochondria by the role of endonuclease G is investigated.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein
Article Abstract:
The p35 protein in Caenorhabditis elegans is a substrate for four CED-3-like vertebrate cysteine protease activities seen in apoptosis in mammals as well as a substrate for and inhibitor of the cell-death protease CED-3. The insertion of the CED-3 cleavage site in p35 into the cowpox virus protein crmA allowed crmA to block both mammalian apoptosis and CED-3-mediated cell death. Therefore, programmed cell death may be prevented by p35 competitively inhibiting cysteine proteases.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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