Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins

Article Abstract:

The interaction of LIM-domain-binding factor 1 (Ldb1) with the LIM homeodomain protein, Lhx1, enables LIM domains to exert a transcriptional regulatory effect on embryonic development. The high affinity binding by Ldb1 requires paired LIM domains. The injection of Xenopus Ldb protein, XLdb1, into embryos results in synergism with the Xenopus orthologue of Lhx1, Xlim-1, to form a partial secondary axes. XLdb1 also activates the genes encoding goosecoid, chordin and NCAM, which reveals the physical interaction between the two proteins.

Analysis, Observations, Genetic transcription, Transcription (Genetics), Protein binding, Xenopus

---

Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice

Article Abstract:

Transgenic mice having less than 2-fold Ets2 overexpression in specific organs develop viscerocranial, neurocranial and cervical skeletal abnormalities similar to those found in humans with Down's syndrome and in trisomy-16 mice. Ets2 participates in skeletal development of things such as cartilage and bone. Skeletal abnormalities in Down's syndrome patients are due to an overexpression of Ets2. Ets2 is overexpressed during murine development in newly forming cartilages.

Genetic aspects, Down syndrome, Bone cells, Proto-oncogenes

---

Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities

Article Abstract:

Pax-2 gene, one of a group of transcription factors that affect embryonic growth, causes the kidneys of transgenic mice to develop abnormally when Pax-2 is not suppressed as it normally is. Deregulation of Pax-2 expression produced renal epithelium with features resembling congenital nephrotic syndrome. Although Pax-2 expression is necessary for the early stages of kidney development, its suppression is essential for later development.

Health aspects, Abnormalities, Physiological aspects, Kidneys, Genetic regulation, Developmental genetics, Kidney

Similar abstracts:

• Abstracts: Interaction of the erythropoietin and stem-cell-factor receptors. The meaning of life
• Abstracts: Production of heparin-binding angiogenic factor(s) by bovine corpora lutea during pregnancy
• Abstracts: Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours. Two nuclear signalling pathways for vitamin D
• Abstracts: Seeing the mantle in the round. Probing Earth's dynamo. Deep thoughts on the mantle
• Abstracts: Climate-induced fluctuations in sea level during non-glacial times. part 2 A balmy Arctic

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.