Involvement of p85 in p53-dependent apoptotic response to oxidative stress
Article Abstract:
It was reasoned that cellular responses to oxidative stress could be mediated by signal-transducing proteins. Protein p85, a regulator of phosphatidyl-3-OH kinase (PI(3)K), a signalling protein, is involved in cell death, and was found to be induced in response to oxidative stress. Cellular apoptotic response to oxidative stress was impaired by disruption of p85 by homologous recombination. The relation between p85 and the protein p53, which is required for cell death, is examined.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone
Article Abstract:
Research has established that epidermal growth factor receptors undergo tyrosine phosphorylation in the presence of growth hormone. The protein Grb2 is involved in the reaction, which also results in the activation of liver mitogen-activated protein kinase. Evidence suggests that Janus kinase Jak2 simulates phosphorylation by gene express and MAP kinase activation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Experience-dependent and cell-type-specific spine growth in the neocortex. Attractor dynamics of network UP states in the neocortex
- Abstracts: Stationary pulses of light in an atomic medium. Interference in the matter. Polarization of the prompt gamma-ray emission from the gamma-ray burst of 6 December 2002
- Abstracts: Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. Control of dynamic CFTR selectivity by glutamate and ATP in epithelial cells