Ipr1 gene mediates innate immunity to tuberculosis
Article Abstract:
A new genetic locus on mouse chromosome 1, designated as sst1(super susceptibility to tuberculosis 1) is found out. The study show that this locus mediates innate immunity in sst1congenic mouse strains and identify a candidate gene, Intracellular pathogen resistance 1(Ipr1), within the sst1 locus.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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The large-conductance Ca (super 2+) -activated K (super +) channel is essential for innate immunity
Article Abstract:
Neutrophil leukocytes have a pivotal function in innate immunity. K (super +) crosses the membrane through large -conductance ca (super 2+) -activated K (super +) channels. The channels were opened by the combination of membrane depolarization and elevated ca (super 2+) concentration.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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The equilibria that allow bacterial persistence in human hosts
Article Abstract:
A new equilibria model that explains the common features of microbial persistence in their human hosts is reported. The model could be used to understand the direction of virulence as the context of human ecology changes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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