Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids
Article Abstract:
Beta-amyloid peptide (A-beta), which forms deposits in the brains of people with Alzheimer's disease, has been detected in cerebrospinal fluid and in conditioned medium of mixed-brain cell cultures. This detection was made with antibodies unique for an epitope within A-beta that covers the site of normal constitutive cleavage. The isolation of A-beta in these two fluids may lead to new methods of diagnosing Alzheimer's disease and to new treatments based on removing cerebral deposits of A-beta.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production
Article Abstract:
A study was conducted to establish genetic determinants of familial Alzheimer's disease (FAD). Cells cultured from a FAD family were found to express DNA which encode the beta-amyloid precursor protein (beta-APP) having mutations at two points. These cells produced six to eight times more of the protein found in cerebral depositions of Alzheimer's patients than in cells expressing normal beta-APP. This is one link between a FAD genotype and its well-known phenotype.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Purification and cloning of amyloid precursor protein Beta-secretase from human brain
Article Abstract:
A membrane-bound enzyme activity cleaving full-length amyloid precursor protein (APP) at the Beta-secretase cleavage site, is described. It is found to be the dominant Beta-cleavage activity in human brain. The enzyme activity was purified using a new substrate analogue inhibitor of the enzyme activity, showing that the purified enzyme has the properties predicted by Beta-secretase.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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