K(sub ATP) channels as molecular sensors of cellular metabolism
Article Abstract:
ATP-sensitive potassium (K(sub ATP)) channel activity provides a link between cellular energetics and electrical excitability. Crystallographic and electrophysiological studies lead to detailed structural and kinetic models that define the molecular basis of channel activity, and the uncovering of disease-causing mutations of K(sub ATP) explains the molecular basis of disease and leads to a better understanding of the structural basis of channel function.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
ATP-dependent reduction of cysteine-sulphinic acid by S.cerevisiae sulphiredoxin
Article Abstract:
A yeast protein of relative molecular mass Mr =13,000, named sulphiredoxin, which is conserved in higher eukaryotes is identified. It is proposed that sulphiredoxin reduces cysteine-sulphinic acids by activating phosphorylation followed by a thiol-mediated reduction step.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
Structure of the sulphiredoxin-peroxiredoxin complex reveals an essential repair embrace
Article Abstract:
The crystal structure of the human sulphiredoxin-peroxiredoxin (Srx-PrxI) complex is discussed. The complex is found to exhibit a complex repair embrace while allowing other proteins to bind to peroxiredoxins (Prxs).
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2008
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: A cGMP-gated cation channel in depolarizing photoreceptors of the lizard parietal eye. Strange case of the third eye
- Abstracts: Negative Poisson's ratios as a common feature of cubic metals. Super-tough carbon-nanotube fibres
- Abstracts: Forest and landscape structure as predictors of capercaillie occurrence. Flight-initiation distance in birds is dependent on intruder starting distance
- Abstracts: Fly eyes get the whole picture. Preserved organs of devonian harvestmen. A fly in the biogeographic ointment
- Abstracts: Adhesion articulated. The molecular architecture of cadherins in native epidermal desmosomes. Direct observation of catch bonds involving cell-adhesion molecules