LAF1 ubiquitination by GOP1 controls photomorphogenesis and is stimulated by SPA1

Article Abstract:

Research has been conducted on GOP1 protein. The authors have demonstrated that this protein functions as E3 ligase and ubiquitinates both itself and the translation activator LAF1 required for phyA responses, and that coiled-coil domain of SPA1 which is a negative regulator of phyA signalling does not affect GOP1 auto-ubiquitination but facilitates LAF1 ubiquitination at low GOP1 concentrations.

Science & research, Molecular Biology, Research, Gene mutations, Gene mutation, Genetic regulation, Genetic transcription, Transcription (Genetics), Morphogenesis, Phytochrome, Photochemistry, Chemical inhibitors, Properties

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Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-(kappa)B

Article Abstract:

Research has been conducted on ubiquitin-specific proteases mediating deubiquitination of cellular substrates. The authors describe the collection of RNA interference vectors designed to suppress human de-ubiquitinating enzymes, and they report that inhibition of these enzymes enhances transcription factor NF-(kappa)B activation.

Netherlands, Proteases, Cell cycle, RNA, Tumor suppressor genes, Apoptosis, Tumour suppressor genes

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Aspirin, ubiquitin and cancer

Article Abstract:

The author discusses tumor-suppressor proteins the loss of which leads to cylindromatosis. The role of proteins NF-(kappa)B and ubiquitin in benign tumour syndrome is analyzed.

Research and Testing Services, Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Cancer & Cell R&D, Aspirin, Aspirin Combinations, Cancer research, Cancer, Oncology, Experimental

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