Leptin activation in hypothalamus
Article Abstract:
The Ob-Rb variant of the leptin receptor gene in obese ob/ob mice is highly expressed in the hypothalamus with the strongest and fastest hypothalamic response occurring in the paraventricular nucleus. Fos protein immunoreactivity studies of the hypothalamic areas involved in leptin protein mediation show dense immunoreactivity in the paraventricular nucleus. The Ob-Rb receptor is possibly located in the paraventricular nucleus. Treatment of the ob/ob mice with leptin restores their hormonal feedback signal and corrects genetic disorders.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Some heat but not enough light
Article Abstract:
New research challenges the conventional view that obese people do not have a deficiency of calorific expenditure. It has been established that the mitochondrial uncoupling protein, which is responsible for uncoupling combustion and ATP synthesis in brown adipose tissue, may have a role in caloric exchange. However, further research must be undertaken into its roles in obesity treatment and pathogenesis. It is possible that it may be misguided to focus solely on calorie intake or expenditure.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
Article Abstract:
Research demonstrates that glucose-receptive hypothalamic neurons of lean Zucker and Sprague-Dawley rats are hyperpolarized by leptin, but that leptin has no effect on obese Zucker rat neurons. The activation of a potassium current causes the hyperpolarization, with leptin removal not making recovery easy. The protein leptin is encoded by the obese gene, with obesity occurring via receptor isoform or leptin mutations in hypothalamic neurons.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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