New variation on the translocation of proteins during early biogenesis of apolipoprotein B
Article Abstract:
Apolipoprotein B (apo B) is a protein secreted by cells, which is necessary for the transport of cholesterol throughout the body. Apo B mediates the uptake of low-density lipoproteins forming a complex that is then soluble in blood. Without the binding of lipids, apo B would not be soluble in liquids. During the synthesis of proteins that will be secreted, the proteins must go from a cellular membrane to a liquid environment. How apo B remained soluble in the liquid was not known. It was shown that apo B is synthesized in a way that is similar to proteins that are associated with the cell membrane, rather than proteins that will be secreted. Apo B is synthesized with segments of amino acids (the building blocks of proteins) that are typical for transmembrane proteins, and are protected against enzymes that would degrade the protein. However, these transmembrane sequences are not inserted into the cell membrane. Knowledge of how apo B is synthesized is important to the understanding of the mechanism of cholesterol removal, which is important to the understanding of heart disease. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1990
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A translocation signal for delivery of oomycete effector proteins into host plant cells
Article Abstract:
The delivery of oomycete effector proteins into the host plant cells by various plant pathogens to establish different diseases is described.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Best packing in proteins and DNA
Article Abstract:
Optimal packing and optimal shapes, such as those naturally occurring helical structures of proteins and DNA are discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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