Noggin the dorsalizer
Article Abstract:
The dorsal blastopore lip of the Xenopus gastrula is responsible for at least three inductive interactions resulting in body plan formation. It causes neural induction, the dorsalization of the mesoderm and the anterior-posterior patterning of the mesoderm. Recent research has shown that a cytokine called noggin may be responsible for the dorsalizing activity. Noggin has been shown to be expressed in adequate quantities at the right stage of embryonic growth to be called a growth inducing factor; a noggin inhibition experiment remains to be performed to confirm this status.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Secreted noggin protein mimics the Spemann organizer in dorsalizing Xenopus mesoderm
Article Abstract:
The dorsal blastopore of the Xenopus gastrula is responsible for several inductive interactions resulting in body plan formation including the dorsalization of the mesoderm. Research shows that the cytokine noggin may be responsible for the dorsalizing activity. The signal from the blastopore, also known as Spemann's organizer, cannot be mimicked by fibroblast growth factor or activin.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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A twist on embryonic signalling
Article Abstract:
Issues are presented concerning the development of a model which details the production of signalling protein gradients during the control of tissue formation in the early development of the fruitfly.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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