Role of tissue factor in embryonic blood vessel development
Article Abstract:
The tissue factor (TF) is essential for the formation of blood vessels and blood circulation in mice. The inactivation of the mouse TF gene causes abnormal circulation from the yolk sac to the embryo after embryonic day 8.5. This leads to embryo wasting and death. TF is also involved in thrombosis and inflammation. It is required for processes like intracellular signalling, metastasis and embryogenesis. The vitelline vessels of mice lacking TF are deficient in smooth-muscle alpha-actin-expressing mesenchymal cells, which are involved in vessel wall organization.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
Article Abstract:
Embryos containing a single inactive vascular endothelial growth factor (VEGF) gene show abnormal development of blood vessels. The homozygous VEGF-deficient embryos exhibit more abnormality in the blood vessel development, and more fatality than heterozygous mutants. The haploid-insufficient phenotype is associated with heterozygous VEGF deficiency. VEGF participation in vascular development depends on the ligand dose. The embryonic phenotypes from germline transmission and aggregation of heterozygous mutant embryo stem cells with tetraploid hosts are similar.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
Article Abstract:
Vascular endothelial growth factor (VEGF), an endothelial cell-specific mitogen, produces the angiogenesis or development of new blood capillaries that is essential for the proliferation of human gliomas, tumors affecting the nervous system. In particular, VEGF was found to be the decisive mechanism for the angiogenesis of glioblastoma, a common and highly malignant form of brain tumor.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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