Osteoclast differentiation and activation
Article Abstract:
This review discusses osteoclastogenesis and bone resorption in terms of the role played by osteoclasts. Research shows that the monocyte/macrophage haematopoietic lineage derived osteoclasts adhere to bone matrix and degrade it in extracellular compartments. The receptor activator of nuclear factor (RANK) signalling pathway in the osteoclasts mediates hormonal signals influencing bone mass and structure.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection
Article Abstract:
Research demonstrates that macrophages, containing the viral replication Nef protein, upon stimulation by CD40 receptor release a paracrine factor that converts T lymphocytes susceptible for HIV-1 infection bypassing cell cycle. Data indicate two soluble proteins, CD23 and ICAM are induced from macrophages by Nef and CD40L.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
Developmental regulation of the growth plate
Article Abstract:
This review discusses endochondral bone formation with respect to the formation of skeleton. Research reveals that the process involves signalling pathways and transcription factors, which control and regulate bone growth plate at the cellular level.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Hox gene variation and evolution. DNA answers the call of pipistrelle bat species. Revised phylogeny of whales suggested by mitochondrial ribosomal DNA sequences
- Abstracts: Phosphorylation and inactivation of the mitotic inhibitor Wee1 by the nim1/cdr1 kinase. Nim1 kinase promotes mitosis by inactivating Wee1 tyrosine kinase
- Abstracts: Seismological evidence for differential rotation of the Earth's inner core. Testing the test-ban treaty
- Abstracts: Expression of the transcription factor delta-FosB in the brain controls sensitivity to cocaine. Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour
- Abstracts: Nanostructures in a new league. Magnetization distribution in the mixed-phase state of hole-doped manganites. View from the edge