PAS is a dimerization domain common to Drosophila period and several transcription factors
Article Abstract:
The period gene product's (PER's) PAS domain of about 270 amino acids may act as a dimerization domain in both the Drosophila melanogaster single-minded gene product (SIM) and the dioxin receptor complex. PER also appears to regulate circadian gene transcription via interactions with the PAS domain of transcription factors containing basic-helix-loop-helix - PAS. PAS mutants appear to interfere with protein-protein interactions, changing circadian rhythms.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Endonucleolytic cleavage of eukaryotic mRNAs with stalls in translation elongation
Article Abstract:
Yeast mRNAs with stalls in translation elongation are recognized and targeted for endonucleolytic cleavage, referred to as 'no-go decay'. No-go decay provides a mechanism for clearing the cell of stalled translation elongation complexes, which occur as a result of damaged mRNAs or ribosomes, or as a mechanism of post-transcriptional control.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Quality control of mRNA3'-end processing is linked to the nuclear exosome
Article Abstract:
Research describing messenger RNA metabolism processes is presented. In particular the contribution of the exosome to proper 3'-end formation of mRNA is investigated.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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