Heparin is essential for the storage of specific granule proteases in mast cells
Article Abstract:
Heparin, a negatively charged glycosaminoglycan, is produced by all mammals. The physiological function of heparin has yet to be determined. Transgenic mice were generated by disrupting the N-deacetylase/N-sulphotransferase-2 gene. They cannot fully express sulphated heparin. Mast cells were developed which contained high levels of certain protease transcripts, but failed to express mMCP-5 and mMC-CPA.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Molecular identification of a volume-regulated chloride channel
Article Abstract:
Research suggests that the putative chloride channel protein CIC-3 is responsible for encoding volume-regulated chloride current in mammalian cells. The functional expression of NIH/3T3 cells is achieved through cloning techniques. Further research is required to ascertain the molecular relationship between cell volume and channel activation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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