Pharmaco-metabonomic phenotyping and personalized drug treatment

Article Abstract:

A description of an alternative and conceptually novel pharmo-metabonomic approach to personalizing drug treatment is provided which uses a combination of pre-dose metabolite profiling and chemometrics to model and predict the responses of individual objects. Proof-of-principle is provided for this approach, which is sensitive to both genetic and environmental influences.

United States, Drug therapy, Nuclear magnetic resonance, Metabonomic analysis

---

Computational redesign of endonuclease DNA binding and cleavage specificity

Article Abstract:

The computational redesign of the cleavage specificity of the intron-encoded homing endonuclease I-MsoI is described using a physically realistic atomic-level forcefield. The results have indicated that computational protein design methods have an important role in the creation of novel highly specific endonucleases for gene therapy and other applications.

Washington, Health aspects, Protein folding, DNA-ligand interactions, DNA binding, Nucleases

---

High-resolution structure prediction and the crystallographic phase problem

Article Abstract:

A new approach to design protein structure models that could provide better solutions to the X-ray crystallographic phase problem in molecular replacement trials is described.

Observations, Proteins, Nuclear magnetic resonance spectroscopy, Protein structure, Computational biology

Similar abstracts:

• Abstracts: Co-evolution of transcriptional and post-translational cell-cycle regulation. Catalytic enantioselective reactions driven by photoinduced electron transfer
• Abstracts: Consumer products leap aboard the nano bandwagon. Enough talk already. Safe handling of nanotechnology
• Abstracts: When the party's over. Regulator under siege
• Abstracts: Importance of SoxE in neural crest development and the evolution of the pharynx
• Abstracts: Water exchange between the subglacial Lake Vostok and the overlying ice sheet. Rapid discharge connects Antarctic subglacial lakes

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.