Picking up the TAB
Article Abstract:
The TATA-box-binding protein-DNA structure along with the knowledge of transcription factor IIA (TFIIA) helps in modeling the TAB complex between TFIIA and the transcription factor IIB. The TAB model will assist in the studies of RNA polymerase (pol) II, which transcribes nuclear genes encoding the mRNA and other small nuclear RNAs. The TAB structure emphasizes the precise functions of TFIIA and TFIIB. TFIIB helps in the stabilization of TBP-DNA and in the recognition of TBIIA by the regulatory proteins and acts as a bridge between TBP and pol II at the transcription site.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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DNA recognition, warts and all
Article Abstract:
The protein complex linking the papillomavirus transcription factor and DNA has a three-dimensional structure featuring a new form of protein architecture and template for DNA-protein interactions. Rashmi S. Hegde and colleagues used X-ray crystallography to determine the transcription factor's structure. This discovery should help bring about a better understanding of how transcription factors recognize particular DNA sequences and thus contribute to determining which genes are used during growth.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Recognizing DNA in the library
Article Abstract:
A novel combinatorial and adaptable approach has been used to provide new information concerning the basic helix-loop-helix (bHLH) DNA binding equipment. Solid-phase peptide synthesis methods and high resolution mass spectrometry was used to look at the role of the loop area in a Drosophila bHLF factor, Deadpan.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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