Potential of stem-cell-based therapies for heart disease
Article Abstract:
The clinical science that is forming the foundation of future approaches to cardiac regeneration is examined, given that the reservoirs of progenitor cells present in the heart are not sufficient to replace acute loss of a large number of cells, but would replace a slow apoptotic loss of cells over a lifetime. Attention is also required in immunological issues surrounding rejection if non- autologous sources of stem cells are used.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair
Article Abstract:
The G-actin sequestering peptide thymosin beta4 that promotes myocardial and endothelial cell migration in the embryonic heart and retains this property in postnatal cardiomyocytes is shown. It is suggested that thymosin beta4 promotes cardiomyocyte migration, survival, and repair and the pathway it regulates may be a new therapeutic target in the setting of acute myocardial damage.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis
Article Abstract:
A demonstration that microRNA-1-1 (miR-1-1) and miR-1-2 are specifically expressed in cardiac and skeletal muscle precursor cells is presented. The results reveal that the miR-1 genes are direct transcriptional targets of muscle differentiation regulators including serum response factor, MyoD and Mef2.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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