Hedgehog signaling in prostate regeneration, neoplasia and metastasis
Article Abstract:
The activity of the Hedgehog (Hh) signaling pathway, which has essential roles in developmental patterning, is required for regeneration of prostate progenitor cells and renders them tumorigenic. The Hh pathway activity is required for regeneration of prostate epithelium propagation of prostate cancer in xenografts and expression of the stem cell renewal factors nestin and Bmi-1 in cancer cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB
Article Abstract:
A study conducted for the identification of TrkB, which is a neurotrophic tyrosine kinase receptor, as a potent and specific suppressor of caspase-associated anoikis of non-malignant epithelial cells, is presented. It is seen that TrkB generates specific and potent pro-survival signal that makes epithelial cells capable of resisting anoikis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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