Projection structure of rhodopsin
Article Abstract:
A projection map of rhodopsin showing the configuration of its helices is presented. Rhodopsin is a visual pigment containing 348 amino acids, and has been characterized as having seveen helices crossing the disk membrane and an extracellular amino-terminus. Reconstitution of bovine rhodopsin into lipid bilayers yieelded 2-dimensional crystals, which were then analyzed by optical diffraction methods. The projection map provides a framework by which the abundant biochemical data for the protein can be interpreted.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Arrangement of rhodopsin transmembrane alpha-helices
Article Abstract:
Research using a nine angstrom projection map of bovine rhodopsin shows that rhodopsin contains seven hydrophobic alpha-helices. The structure of frog rhodopsin has been established using electron micrographs of frozen-hydrated two-dimensional crystal samples. The tilt angles of each helix has been estimated. Evidence suggests that helices one and two are connected in some way.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Observations of light-induced structural changes of retinal within rhodopsin
Article Abstract:
A new study uses high-resolution, solid-state NMR to determine the light-induced structural changes of 11-cis retinal bound to the mammalian light-receptor rhodopsin.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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