Generation of a functional mammary gland from a single stem cell
Article Abstract:
A single cell, marked with a LacZ transgene, reconstitute a complete mammary gland in vivo. The transplanted cell contributed to both the luminal and myoepithelial lineages and generated functional lobuloalveolar units during pregnancy and the self-renewing capacity of these is demonstrated by serial transplantation of clonal outgrowths.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Developmental biology: Cell fate in the mammary gland
Article Abstract:
The GATA-3 protein has guided immature breast cells on their developmental path to form luminal epithelian cells and a link is found between GATA-3 and two additional gene-regulatory factors, FoxA1 and oestrogen receptor [alpha] (ER[alpha]). The analysis of this GATA-3 protein has shown that this pathway is involved in mammary tumors.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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