Reaction discovery enabled by DNA-templated synthesis and in vitro selection
Article Abstract:
A reaction discovery approach that uses DNA-templated organic synthesis and in vitro selection to simultaneously evaluate many combinations of different substrates for bond-forming reactions in a single solution is reported. An efficient and mild carbon-carbon bond-forming reaction is discovered by using this approach that generates an enone from an alkyne and alkene using an inorganic palladium catalyst.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Sacrificial synthesis
Article Abstract:
An innovative approach for preparing much sought-after polymer molecule chains with just one chemical group attached at the end with excellent control over the chain length is described. Such structures are of interest in molecular engineering because they are potential building blocks for nanocomposite materials or for biological-synthetic macromolecules.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Brevity for bonds
Article Abstract:
Three basic approaches to squeezing carbon-carbon (C-C) bonds, namely caging, crowding and clamping are proposed and examined. In the end, investigating the concept of relative molecular compressibility teaches more about the behavior of molecules than about the size of the deviation from the normal bond length of 1.53 A.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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