p53 and treatment of bladder cancer
Article Abstract:
Adjuvant chemotherapy which includes DNA-damaging agents has lowered by threefold the recurrence risks of patients with p53-altered tumors. It also raised their chances of survival by 2.6-fold. On the other hand, adjuvant chemotherapy did not provide any recurrence or survival benefit to patients with tumors that did not show p53 alterations. This implies that only patients having p53-altered tumors benefit from adjuvant chemotherapy.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Epigenetics in human disease and prospects for epigenetic therapy
Article Abstract:
The term 'epigenetics' describes all meiotically and mitotically heritable change in gene expression that is coded in DNA sequence. Explaining the whole bandwidth of epigenetic mechanisms will lead to a clearer understanding of human disease and direct therapeutic concepts into new directions.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Expandable DNA repeats and human disease
Article Abstract:
The article explores the mechanisms of RNA (ribonucleic acid) and DNA (deoxyribonucleic acid) repeat expansions and replications which result in diseases in human beings.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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- Abstracts: Control and detection of chemical reactions in microfluidic systems. DNA amplification moves on
- Abstracts: Average remaining lifetimes can increase as human populations age. Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
- Abstracts: Damage control. The DNA sequence and analysis of human chromosome 6. The DNA sequence and comparative analysisof human chromosome 10
- Abstracts: The structure and evolution of centrometric transition regions within the human genome. Genomes for medicine