Role for c-Abl tyrosine kinase in growth arrest response to DNA damage
Article Abstract:
The c-Abl protein tyrosine kinase arrests cells in the G1 phase by a mechanism dependent on the p53 tumor suppressor protein in response to DNA damage. Both wild type and inactive c-Abl stimulate the activity of p53 and p21, a p53 effector, in MCF-7 cells exposed to ionizing irradiation. However, only wild-type c-Abl arrests growth by suppressing cyclin-dependent kinase 2 activity. The activity of p21 is unessential for growth arrest as c-Abl arrests growth in cells lacking p21 but not in those lacking p53. The kinase-defective c-Abl mutant stimulates p53 but is unable to arrest growth.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 null mice
Article Abstract:
The myogenic transcription factor, Myf-5 protein, is essential for the cells' response to positional cues in the mice embryo and helps them adopt a myogenic fate. The targeting of the nlacZ reporter gene into the myf-5 locus demonstrates that beta-galactosidase muscle progenitor cells are present in the dermomyotome of myf-5 null embryos. These cells undergo a normal epithelial to mesenchymal transition, but migrate abnormally. The cells accumulates dorsally under the ectoderm, whereas ventrally they fail to localize correctly and are found in ribs.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Role for a Xenopus Orc2-related protein in controlling DNA replication. Springtime in the desert
- Abstracts: A protein kinase encoded by the t complex responder gene causes non-mendelian inheritance. Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor
- Abstracts: A bad kinase makes good. Chemokines beyond inflammation
- Abstracts: Non-centrosymmetric superlattices in block copolymer blends. Quantum confinement and light emission in SiO2/Si superlattices
- Abstracts: Membrane-anchored aspartyl protease with Alzheimer's disease Beta-secretase activity. Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need