Same clock, different works
Article Abstract:
The expression of per clock gene in Drosophila melanogaster (fruitfly) and Antheraea pernyi (giant silkmoth) was studied. Although the gene dictates rhythmic control of biological processes in both insects, it was found that there are more nerve cells bearing the gene in the fruitfly compared to that in the silkmoth. The PER protein was found to be localized in the nucleus of the fruitfly neuron while it exhibits cytoplasmic distribution in the silkmoth cells. The regulation of gene expression is by a regulatory feedback loop in the fruitfly while in the silkmoth, it is through dynamic hybridization with antisense RNA. Translation to protein is synchronous with transcription in the silkmoth but is delayed in the fruitfly.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Metabolic clockwork
Article Abstract:
Researchers have provided an interesting interpretation of the molecular pathways that are implicated in the circadian control of energy metabolism by placing the transcriptional regulator PGC-1[alpha] in a strategic position. The analysis has suggested that the cycling energy metabolism is mediated by an activator of gene expression.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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CLOCK-mediated acetylation of BMAL1 controls circadian function
Article Abstract:
The application of the CLOCK complex in mediating the acetylation of BMAL1 on a highly conserved Lys537 residue is discussed. The analysis reveals that CLOCK-BMAL1 complex is very beneficial in controlling the circadian function.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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