Risk of severe asthma episodes predicted from fluctuation analysis of airway function
Article Abstract:
Asthma is a chronic inflammatory disease of the airways where the time series of peak expiratory flows is analyzed and a standard measurement of airway function assesses twice daily in a large asthmatic population during a longterm crossover clinical trial and an approach is introduced to predict the risk of worsening airflow obstruction by calculating the conditional probability that a severe obstruction occurs in thirty days. The increased variability and loss of correlations augment the risk of unstable airway function and the characterization of fluctuations in airway function provide a quantitative basis for objective risk prediction of asthma episodes and for evaluating the effectiveness of therapy.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Risk of severe asthma episodes predicted from fluctuation analysis of airway function
Article Abstract:
Asthma is a chronic inflammatory disease of the airways where the time series of peak expiratory flows is analyzed. The increased variability and loss of correlations augment the risk of unstable airway function and the characterization of fluctuations in airway function provide a quantitative basis for objective risk prediction of asthma episodes and for evaluating the effectiveness of therapy.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
An optimal bronchial tree may be dangerous
Article Abstract:
A study of the compatibility between physical optimization and physiological robustness in the design of the human bronchial tree is presented. Results showed that bronchial malfunction related to asthma is a necessary consequence of the optimized efficiency of the tree structure.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
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