Silencing and DNA repair connect
Article Abstract:
Recent research has shed new light on silencing and chromatin organization. It has been established that yeast Sir2, Sir3 and Sir4 proteins, which are linked with chromatin and with transcriptional silencing, also play a role in the repair of DNA damage caused by ionizing radiation. This discovery may give information about the way in which DNA double-strand breaks are rejoined. It is also possible that the Sir proteins target Ku, a protein which binds to DNA double-strand breaks, to certain heterochromatic regions when DNA damage is not present.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Repair of DNA loops involves DNA-mismatch and nucelotide-excision repair proteins
Article Abstract:
DNA lesions are recognized and repaired by various enzymes. In the yeast Saccharomyces cerevisiae, failure to repair mismatches causes post-meiotic segregation, while repair of the mismatch results in gene conversion and restoration. Research shows that the DNA-mismatch repair protein msh2 is required mainly for restoration-type repair for his4-lopd and conversion-type repair for his4-AAG.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
Article Abstract:
Research on the Ku heterodimer is examined in detail, with its implications for repair of double-strand breaks an support for broken ends of DNA.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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