Sinking surveillance's flagship
Article Abstract:
Epstein-Barr virus (EBV) is a potentially tumorigenic virus with transforming powers manifested in its ability to alter human B lymphocytes into immunoblasts. EBV hides mainly in the immune system of healthy EBV carriers and equilibrium is maintained by a balance between viral gene expression regulation and the immune system, T cells in particular. Infections can upset the equilibrium. Coffey and colleagues have reported the positional cloning of the X-linked lymphoproliferative syndrome (XLP) gene, known as SH2DaA, and found that it was mutated in nine out of 16 unrelated XLP patients.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1
Article Abstract:
The repetitive sequence, Gly-Ala, of the Epstein-Barr virus-encoded nuclear antigen (EBNA1) generates a cis-acting inhibitory signal that disturbs antigen processing and major histocompatibility complex (MHC) class I-restricted presentation. It acts as a mechanism to avoid cytotoxic T lymphocyte recognition without immunosuppression but rather immune evasion, possibly encouraging the long-term survival of virus-infected cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Bridge or ravine?
Article Abstract:
The gap between scientific and non-scientific cultures is examined in detail, as are ways in which biologists can communicate with social scientists.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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