Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
Article Abstract:
The increased expression of PNC1 (pyrazinamidase/nicotinamidase 1), which encodes enzyme for deamination of nicotinamide, are necessary for lifespan extension by calorie restriction and low-intensity stress are investigated. The mechanism of PNC1 in regulating longtivity and activating Sir2 are analyzed.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
Calories, Health aspects, Longevity, Niacinamide
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Article Abstract:
Restricting caloric intake in metazoans can extend the lifespan of numerous species. Lifespan extension in budding yeast Saccharomyces cerevisiae is dependant on functional Sr2.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
United States, Metazoa, Metazoans, Life spans (Biology), Life span (Biology)
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
Subjects list: Research, Brewer's yeast, Saccharomyces cerevisiae
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