Smart transcription factors

Article Abstract:

A link is developed between cognitive function and the regulation of gene expression by showing that the mental retardation disease Rubinstein-Taybi Syndrome (RTS) is associated with mutations in the transcription co-activator CREB-binding protein (CBP). However, important questions about the RST and CBP connection remain due to the poorly understood nature of defects in RTS patients. Drugs that act on the cAMP signalling pathway may be useful in treating RTS patients and raise the possibility of enhancing memory and cognitive functions.

Genetic regulation, Protein binding, Mental retardation, Cognitive psychology, Rubinstein-Taybi syndrome

---

A protein related to extracellular matrix proteins deleted in the mouse mutant reeler

Article Abstract:

Reeler allele-deficient mice show neuronal migration defects, characterized by tremors, ataxia and impaired motor coordination. The reelin gene is expressed by normal mice in embryonic and postnatal neurons during neuronal migration, suggesting the autosomal recessive mouse mutation reeler prevents the expression of reelin. Though reelin is expressed in humans, it has not been linked to any human genetic diseases but a gene with similar protein characteristics is liked to a neuronal migration defect.

Proteins, Neurons, Genetic disorders

---

Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice

Article Abstract:

Scrambler and yotari, autosomal recessive mouse mutations, arise from mutations in mdab1, a mouse gene connected with the Drosophila gene disabled (dab). Mutated forms of mdab1 messenger RNA are expressed by both scrambler and yotari mice. They express little or no mDab1 protein. It appears that mdab1-expressing cells are exposed to Reelin at the time and location in which developmental abnormalities can be seen in reeler mice. Reelin may activate a tyrosine-phosphorylation pathway.

Gene mutations, Gene mutation

Similar abstracts:

• Abstracts: Nuclear organization of the genome and the potential for gene regulation. Structural basis for redox regulation of Yap1 transcription factor localization
• Abstracts: Using anal gland secretion to determine sex in beaver. Sibling recognition in the beaver: a field test for phenotype matching
• Abstracts: NASA lines up for a bigger slice of the biological research pie. NASA seeks a better, faster distribution of space data
• Abstracts: Market for superconductors is expected to soar by 2020. Blood scandal and E. coli raise questions in Japan. Japan tackles downturn in science funding
• Abstracts: A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin. Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.