Spatially regulated ubiquitin ligation by an ER/nuclear membrane ligase

Article Abstract:

Doa10 (or Ssm4), a yeast transmembrane ubiquitin ligase (E3), is shown to reach the inner nuclear membrane. The localization of Doa10 to the inner nuclear membrane is necessary for nuclear substrate degradation, indicating that difference membrane ubiquitin ligases are spatially sorted within the endoplasmic reticulum (ER)-nuclear envelope membrane system and that this differential localization contributes to their specificity.

Connecticut, Endoplasmic reticulum, Ubiquitin-proteasome system

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Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease

Article Abstract:

The crystal structures of human cleavage and polyadenylation specificity factor (CPSF-73), complexed with zinc ions and a sulphate that might mimic the phosphate group of the substrate and the related yeast protein CPSF-100 (Ydh1), are presented. The results have shown that the CPSF-73 is the pre-mRNA 3'-end-processing endonuclease.

New York, Observations, Protein synthesis, Protein biosynthesis, Crystals, Crystal structure, X-rays, X-ray diffraction, Nucleases

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ESCRT service

Article Abstract:

The article discusses the endosomal sorting complex required for transport - I (ESCRT-I) which is a cytoplasmic component and necessary for the formation of multivesicular bodies in organisms.

United States, Membrane proteins, Protein binding, Cell research, Cytological research, Homeostasis

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