Stabilization of wild-type p53 by hypoxia-inducible factor 1-alpha
Article Abstract:
Research into the mechanism of the induction of the wild-type p53 gene indicates that hypoxic induction of transcriptionally active wild-type p53 is achieved as a result of the stabilization of p53 by its links with desferrioxamine activate hypoxia-inducible factor 1-alpha (HIF-1-alpha). It appears that p53 accumulation is a result of protein stabilization, and thus not dependent on HIF-1-alpha-mediated transcriptional activity. Induction of p53 does not take place in a mutant heptoma line unable to induce HIF-1-alpha or in embryonic stem cells derived from mice lacking HIF-1-beta.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Upwelling-driven nearshore hypoxia signals ecosystem and oceanographic changes in the northeast Pacific
Article Abstract:
The unprecedented development of severe inner-shell hypoxia and resultant mass die-offs of fish and invertebrates within the California Current System is presented. The findings focus the sensitivity of inner-shelf ecosystems to variation in ocean conditions and the potential impacts of climate change on marine communities.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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S-nitrosothiols signal the ventilatory response to hypoxia
Article Abstract:
It has been possible to identify a pathway in which raised minute ventilation is signalled by deoxyhaemoglobin-derived S-nitrosothiols. It was found that plasma from deoxygenated blood prompts the ventilator effect of both S-nitrosothiols and hypoxia.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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