Structural basis for the anticoagulant activity of the thrombin-thrombomudulin complex
Article Abstract:
The 2.3A crystal structure of human alpha-thrombin required for TM456 activity is presented. TME45 may bind substrates in such a way that they are presented unaltered thrombin active site.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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Staphylocoagulase is a prototype for the mechanism of cofactorinduced zymogen activation
Article Abstract:
The importance of isoleucine 1 and valine 2 at the amino terminus f staphylocoagulase for zymogen activation is confirmed by the kinetic studies. The staphylocoagulase fold is conserved in other bacterial plasma-protein-binding factors and extracellur-matrix-binding factors.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1
Article Abstract:
Matrix metalloproteinases (MMPs) are needed for embryo development, morphogenesis and tissue remodelling metalloproteinase (TIMP) tissue inhibitors regulate their proteolytic activities. Any disruption can lead to diseases such as tumour growth and arthritis. It is reported that the crystal structure of an MMP-TIMP complex formed between MMP-3 and human TIMP_1 is elongated in a continuous wedge shape. The unusual architecture indicates new possibilities for the design of TIMP variants and synthetic MMP inhibitors.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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- Abstracts: Single-molecule studies of the effect of template tension on T7 DNA polymerase activity. The bacteriophage phi-29 portal motor can package DNA against a large internal force
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