Stepping up the pressure
Article Abstract:
The long-sought molecular cloning of the human V2 vasopressin receptor has been achieved by two research groups. Vasopressin is a peptide hormone that acts on mammalian tissues and may affect G protein-coupled receptors in many ways, with the regulation of water retention by the kidneys being the most commonly known. The genetic sequence of V2 vasopressin receptors has a striking resemblance to the V1 vasopressin and oxytocin receptors, a result that may lead to further research on receptor structure and physiological function.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Cloning and expression of human TAFII250: a TBP-associated factor implicated in cell-cycle regulation
Article Abstract:
The relationship between TATA-binding protein (TBP) and TBP-associated factors (TAFs) was examined. The first human TAF, hTAFII250, was cloned, expressed and characterized. The hTAFII250 gene was found to be identical to a gene that has been implicated in cell-cycle progression. In addition, the recombinant hTAFII250 participates in the formation of the TFIID complex. These findings indicate that hTAFII250 interacts with both TBP and other TAFs in TFIID assembly, as well as links the control of transcription to the cell cycle.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes
Article Abstract:
The gene for the third intercellular adhesion molecule (ICAM-3) ligand for the leukocyte function-associated antigen-one (LFA-1) has been cloned from its complementary DNA. Like the previously known ICAM-1 and ICAM-2, ICAM-3 is an immunoglobulin-based molecule. ICAM-3 appears to trigger the immune response among inactive leukocytes. It contains five immunoglobulin domains, uses two N-terminal domains to link to LFA-1 and is similar in form to ICAM-1.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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