Structural basis for inhibition of the replication licensing factor Cdt1 by geminin
Article Abstract:
tGeminin and tCdt1 are used for describing the crystal structure of the mouse geminin-Cdt1 complex. The crystal structure and the data collected suggests that the N-terminal region of tGeminin might be required for anchoring tCdt1 and the access of MCM complex to tCdt1 through steric hindrance is prevented by the C-terminal region of the tGeminin.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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A destructive switch for neurons
Article Abstract:
The triggering mechanism within neuroblasts that stop the cell-division cycle and trigger the activation of the programme that extends the axon is studied. The results of the study open a new link between the mechanism that causes the cell to cease division and the activation of the gene-expression programme that directs neuronal function.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Centre- surround inhibition among olfactory bulb glomeruli
Article Abstract:
The so called 'short axon' cells sending interglomerular axons over long distances to from excitatory synapses with inhibitory periglomerular neurons up to 20- 30 glomeruli away is shown. Interglomerular excitation of these periglomerular cells potently inhibits mitral cells and forms an on centre, off surround circuit.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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- Abstracts: Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules
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