IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro
Article Abstract:
The self-renewal and pluripotent properties of human embryonic stem (ES) cells have depended on a dynamic interplay between human ES cells and autologously derived human ES cell fibroblast-like cells (hdFs). The studies have shown a direct role of the insulin-like growth factor II (IGF-II)/IGF 1 receptor (IGF1R) axis on human ES cell physiology and has established that hdFs produced by human ES cells themselves define the stem cell niche of pluripotent human stem cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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A candidate NAD(super +) transporter in an intercellular bacterial symbiont related to chlamydiae
Article Abstract:
A report on the identification of a candidate transporter protein from UWE25 that is highly specific for import of nicotinamide adenine dinucleotide (NAD)(super +) when synthesized heterously in Escherichia coli is presented. This candidate NAD(super +)/ADP exchanger demonstrates that intact NAD(super +) molecules can be transported through cytoplasmic membranes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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An ABC transporter with secondary-active multidrug translocator domain
Article Abstract:
The human cells became resistant to multiple unrelated pharmaceuticals due to the removal of drugs from the cells interior by means of a transporter. The discovery of a truncated LmrA protein that lacks the ATP-binding domain, a primary drug transporter in the Lactococcus lactis, is described.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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