Structure of the S-adenosylmethionine riboswitch regulatory mRNA element
Article Abstract:
The 2.9-Angstrom resolution crystal structure of an S-adenosylmethionine (SAM)-responsive riboswitch from Thermoanaerobacter tengcongensis complexed with S_adenosylmethionine, an RNA element is described that controls the expression of several genes involved in sulphur and methionine metabolism. Ligand binding induces the formation of a series of tertiary interactions with one of the helices, serving as a communication link between the aptamer and expression platform domains.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF
Article Abstract:
A molecular basis is demonstrated for specific recognition of H3(1-15)K4me3 by a plant homeodomain (PHD) finger of human bromodomain and PHD domain tanscription factor (BPTF), the largest subunit of the ATP-dependent chromatin-remodeling complex nucleosome remodeling factor (NURF). Binding studies establish that the BPTF PHD finger exhibits a preference for K4me3-containing H3 peptides, and key specificity-determining residues are identified.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Structural basis for gene regulation by a thiamine pyrophosphate-sensing riboswitch
Article Abstract:
Riboswitches are metabolite-sensing RNAs, typically located in the-coding portions of messenger RNAs that control the synthesis of metabolite-related proteins. A 2.05-Angstrom crystal structure of a riboswitch domain from the Escherichia coli thiM mRNA is described that responds to the coenzyme thiamine pyrophosphate (TPP).
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Structure of the yeast polarity protein Sro7 reveals a SNARE regulatory mechanism. How to build a cell junction
- Abstracts: Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA. Crystal structure of the CorA M[g.sup.2+] transporter
- Abstracts: Modification by nuclear export? Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA
- Abstracts: Critical role for the p110[alpha] phosphoinositiude-3-OH kinase in growth and metabolic regulation. Essential role for the p110delta phosphoinositide 3-kinase in the allergic response
- Abstracts: A game of subversion. Stem cells for the treatment of neurological disorders. Stem cells, ageing and the quest for immortality