Synaptic code for sensory modalities revealed by C. elegans GLR-1 glutamate receptor
Article Abstract:
Differential secretion of ASH neurotransmitters in response to distinct stimuli is responsible for differentiation between the ASH sensory modalities in Caenorhabditis elegans. Functional GLR-1 is essential to regulate normal nose-touch response in forward and backward command neurons but not for osmotic repellents. GLR-1 receptors mediate the activity of RMD neurons. Mutations that rupture the ASH-regulated touch response are screened. Mutant glr-1 are defective for harsh-touch sensitivity but are normal to light-touch sensitivity.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Mechanosensory signalling in C. elegans mediated by the GLR-1 glutamate receptor
Article Abstract:
The GLR-1 glutamate receptor is necessary for ASH neurons to induce mechanical avoidance behavior in Caenorhabditis elegans. It does not play any role in chemical avoidance behavior. ASH neurons may release multiple transmitters due to the presence of both dark and clear synaptic vesicles. The use of degenerate polymerase chain reaction helps in the analysis of the function of the GLR-1 and the expression pattern is determined in transgenic worm strains expressing reporter genes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Molecular basis of mechanosensory transduction
Article Abstract:
Recent research in both vertebrates and invertebrates is starting to show the identities of proteins vital for transduction. Mechanisms of mechanosensory transduction by vertebrates and invertebrates are discussed, with emphasis on the growing molecular understanding of transduction.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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