Synthesis with a twist
Article Abstract:
Amide is one of the most fundamental functional groups in chemistry, a link between amino acids in peptides and proteins, and thus a key to the structure of many biological systems. Amides are surprisingly robust compared with structurally related derivatives, and it is believed that this linkage gains stability from electron delocalization and the amide group can be thought of in terms of two structures, one of which is apolar, and the other dipolar.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Synthesis and structural analysis of 2-quinuclidonium tetrafluoroborate
Article Abstract:
Typical acyclic amides are planar, but the amide groups of bicyclic bridgehead lactams are highly twisted, and this distortion from planarity can dramatically affect the stability and reactivity of these amides, increasing the basicity of the nitrogen so that it often behaves more like an amine than a typical planar amide. As a result, the structures and reactivity profiles of these anti-Bredt amides differ significantly from those of planar amides.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Synthesis and structure of a layered titanosilicate catalyst with five-coordinate titanium. Controlling molecular deposition and layer structure with supramolecular surface assemblies
- Abstracts: Biodiesel made with sugar catalyst. Testis determination requires insulin receptor family function in mice
- Abstracts: Say it with leaves. The fuzzy frontier: the story of how feathers evolved is far from over. Butch Fossa
- Abstracts: Use of tree stumps as roosts by the western long-eared bat. Fine-scale analysis of Mount Graham red squirrel habitat following disturbance
- Abstracts: Information propagation. Electronic tagging and population structure of Atlantic bluefin tuna. Friction enhances elasticity in granular solids