Synthetic lethal screen identification of chemosensitizer loci in cancer cells
Article Abstract:
A combination of a screening platform with a synthetic library of RNAs is used for a paclitaxel-dependent synthetic lethal screen that is designed to identify various gene targets that reduce the cell viability in the presence of sublethal concentrations of paclitaxel. The analysis reveals that most of such targets sensitize lung cancer cells, as several mechanistic relationships exist between the cancer-associated gene expression programs, as well as the basic cellular machinery required in the progression.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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When the junk isn't junk
Article Abstract:
Introns have been considered examples of 'junk DNA,' a description for chromosomal sequences having no apparent function. This view was shattered by results of a cloning project aimed at sequencing the mouse UHG. UHG was found to be an example of an 'inside-out' gene wherein only introns encode function. The UHG structure is not believed to be unique, so further research could reveal other conserved intronic sequences.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Failure of B-cell differentiation in mice lacking the transcription factor EBF
Article Abstract:
Targeted gene disruption in mice revealed that the early B-cell factor (EBF) is essential for the generation of immunoglobulin expressing B cells. The results indicate a major role for EBF in the transcriptional regulation of B-cell differentiation in a step which lies between the immunoglobulin gene rearrangement step and the step in which commitment of cells to the B-lymphoid lineage occurs.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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