TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity
Article Abstract:
The amino-terminal caspase recruitment domains (CARDs) of retinoic-acid-inducible gene-I (RIG-I) have undergone robust ubiquitination that is induced by tripartite motif 25 (TRIM25) in mammalian cells. The analysis show that TRIM25 E3 ubiquitin ligase induces the Lys63-linked ubiquitination of RIG-I that is very important for the cytosolic RIG-I signalling pathway to elicit host antiviral innate immunity.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
Article Abstract:
The article discusses the various effects of the TANK-binding kinase-1 (TBK1) on the impact of the DNA vaccines on the immune responses in humans. The findings show that TBK1 is a very important molecule for DNA-vaccine-induced immunogenicity, as it helps in controlling the immune signaling through haematopoietic cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2008
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Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
Article Abstract:
The effect of cryopyrin deficiency on inflammasome function and immune responses are examined. Results reveal a critical role for cryopyrin (also called Nalp3) in host defence through bacterial RNA-mediated activation of caspase-1, and provide insights regarding the pathogenesis of autoinflammatory syndromes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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