CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
Article Abstract:
Fasting hyperglycaemia and lowered expression of gluconeogenic enzymes arise in mice carrying a targeted disruption of the cyclic AMP response element binding (CREB) protein gene, or excessively expressing a dominant-negative CREB inhibitor. It is suggested that activation of PGC-1 by CREB in the liver plays a significant role in the pathogenesis of hepatic gluconeogenesis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
Article Abstract:
Hormonal and energy-sensing pathways converge on the coactivator transducer of regulated CRE binding protein (CREB) activity 2 [TORC2] to modulate glucose output. The signals that activate AMPK attenuate the gluconeogenic programme by promoting TORC2 phosphorylation and blocking its nuclear accumulation and individuals with type 2 diabetes often exhibit fasting hyperglycaemia due to elevated gluconeogenesis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2
Article Abstract:
The effect of insulin during feeding in mice is studied. Results reveal that insulin modulates gluconeogenic gene expression during re-feeding by boosting the phosphorylation and ubiquitin-dependent degradation of TORC2.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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