The cancer-chromatin connection
Article Abstract:
Mutation of a tumour-suppressor pathway, involving the production of the retinoblastoma (Rb) gene, is a pathway for nearly all cancer cells. Magnaghi-Jaulin and colleagues have provided an insight into the Rb's ability to repress gene expression, producing a link between Rb and the histone deacetylase HDAC1. Chromatin regulation is thus implicated in cell-cycle control and the Rb/HDAC1 complex may be a possible target of transforming viruses.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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The oncogene and polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
Article Abstract:
Bmi-1-deficient primary mouse embryonic fibroblasts were found to be impaired when moving into the S phase of the cell cycle, and they undergo premature senescence. Tumour suppressors p16 and p19Arf expression is markedly raise in such fibroblasts and in bmi-1-deficient lymphocytes. Lymphoid and neurological defects are dramatically reduced on removal of ink4a.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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The age of cancer
Article Abstract:
Issues surrounding the close link between advanced age and a greater incidence of cancer are discussed. Particular focus is given to the predominance of epithelial cancers, which might be due to a combination of age-related physiological and molecular changes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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- Abstracts: p53 sends nucleotides to repair DNA. Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis
- Abstracts: The E. coli ffh gene is necessary for viability and efficient protein export. YidC mediates membrane protein insertion in bacteria
- Abstracts: Evidence for a selectively favourable reduction in the mutation rate of the X chromosome. The proteins of linked genes evolve at similar rates
- Abstracts: The effect of recent experience on female choice in zebra finches. Men's voices and women's choices
- Abstracts: Chemical and biological trends during lake evolution in recently deglaciated terrain. A lake's life is not its own