The product of 'hedgehog' autoproteolytic cleavage active in local and long-range signalling
Article Abstract:
The identification and study of the autoproteolytic cleavage site reveals that the site is broadly conserved throughout the hedgehog family. The identification of the site also facilitates the determination of the C and N cleavage products found in the assays of Drosophila. The N product is found to be associated with the long-range and local signalling. The hedgehog structure is also found to influence the C and N cleavage functions.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
Article Abstract:
Sonic hedgehog (Shh), a mammalian hedgehog pathway ligand, and development of airway epithelium during repair of acute airway injury from small-cell lung cancer are researched. Includes cellular photographs, graphs and photographs.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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Hedgehog regulates smoothened activity by inducing a conformational switch
Article Abstract:
The Hedgehog (HH)-induced phosphorylation in Drosophila melanogaster which activates seven-transmembrane protein smoothened (SMO) by inducing a conformational switch is reported.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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