The synaptic vesicle cycle: a cascade of protein-protein interactions

Article Abstract:

Synaptic transmission, a mode of information exchange in the brain, is the fastest cellular transport pathway and is tightly regulated. It consists of vesicle exocytosis by membrane fusion with neurotransmitter release, endocytosis of empty vesicles and regeneration of vesicles. Molecular models for key steps of the cycle formulated by a convergence of results may give mechanistic understanding of higher neural function, membrane transport and the properties and designs of neural networks.

Models, Computer networks, Neural networks

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Neighbourly synapses

Article Abstract:

A micrometer-scale study, done to find the impact of the induction of an activity-dependent form of synaptic plasticity, called as long-term potentiation (LTP), at one synapse on the properties of its immediate neighbors, is described.

United States, Neuroplasticity, Long-term potentiation

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A dual-[Ca.sup.2+]-sensor model for neurotransmitter release in a central synapse

Article Abstract:

The article discusses photolysis experiments of caged [Ca.sup.2+] that quantitatively describes the contribution of asynchronous neurotransmitter release in calyx-of-Held synapses.

Calcium ions

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